Recurrent anomalies of 6q25 in chondromyxoid fibroma

Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6) (p25q13)]...

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Veröffentlicht in:Human pathology 2000-03, Vol.31 (3), p.306-311
Hauptverfasser: Safar, Aida, Nelson, Marilu, Neff, James R., Maale, Gerhard E., Bayani, Jane, Squire, Jeremy, Bridge, Julia A.
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Sprache:eng
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Zusammenfassung:Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6) (p25q13)] has been proposed as a specific genetic marker for chondromyxoid fibroma. In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoid fibroma cases showed clonal abnormalities of chromosome 6 but at a breakpoint on the long arm (q25) distal to that described in the pericentric inversion. These findings suggest that several distinct breakpoints on chromosome 6 are nonrandomly involved in chondromyxoid fibroma.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(00)80243-9