Roles and Mechanisms of Action of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Growth Hormone and Prolactin Secretion

It appears that PACAP has a direct action on somatotrophs to releaase GH. The intracellular signal transduction mechanisms for PACAP might be similar to but partly distinct from those for GRH. PACAP might play a role in GH secretion induced by serotoninergic mechanisms but not in ultradian rhythm of...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2001, Vol.48(2), pp.123-132
Hauptverfasser:	MURAKAMI, YOSHIO, KOSHIMURA, KUNIO, YAMAUCHI, KATSUMI, NISHIKI, MASATERU, TANAKA, JUNKO, KATO, YUZURU
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Animals Cells, Cultured Growth Hormone - metabolism Humans Hypothalamus - chemistry Hypothalamus - drug effects Hypothalamus - physiology Neuropeptides - analysis Neuropeptides - pharmacology Neuropeptides - physiology Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary Gland - chemistry Pituitary Gland - drug effects Pituitary Gland - physiology Pituitary Neoplasms - metabolism Prolactin - metabolism Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Hormone - analysis Receptors, Pituitary Hormone - physiology
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Zusammenfassung:	It appears that PACAP has a direct action on somatotrophs to releaase GH. The intracellular signal transduction mechanisms for PACAP might be similar to but partly distinct from those for GRH. PACAP might play a role in GH secretion induced by serotoninergic mechanisms but not in ultradian rhythm of GH secretion in the rat. PACAP can stimulate PRL release from the pituitary in rats possibly through indirect paracrine effect. In addition, PACAP might participate in regulation of PRL secretion via hypothalamic VIP.
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.48.123