Effect of pravastatin in mildly hypercholesterolemic young men on serum matrix metalloproteinases

Pravastatin decreases serum MMP-9 concentration in clinically healthy men. This may reflect reduction of nonsymptomatic chronic arterial inflammation.

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Veröffentlicht in:	The American journal of cardiology 2001-07, Vol.88 (2), p.173-175
Hauptverfasser:	Kalela, Anne, Laaksonen, Reijo, Lehtimäki, Terho, Koivu, Tommi A., Höyhtyä, Matti, Janatuinen, Tuula, Pöllänen, Perttu, Vesalainen, Risto, Saikku, Pekka, Knuuti, Juhani, Nikkari, Seppo T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Biological and medical sciences Cardiology Cholesterol Double-Blind Method Drug therapy General and cellular metabolism. Vitamins Genotype Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia - drug therapy Hypercholesterolemia - enzymology Lipids Male Matrix Metalloproteinase 9 - blood Matrix Metalloproteinase 9 - drug effects Matrix Metalloproteinase 9 - genetics Medical sciences Men Pharmacology. Drug treatments Polymorphism, Genetic Pravastatin - pharmacology Pravastatin - therapeutic use Proteins
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Beschreibung
Zusammenfassung:	Pravastatin decreases serum MMP-9 concentration in clinically healthy men. This may reflect reduction of nonsymptomatic chronic arterial inflammation.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(01)01616-2