Stimulation of myocardial Na(+)-independent Cl(-)-HCO(3)(-) exchanger by angiotensin II is mediated by endogenous endothelin

Experiments were performed in isolated cat papillary muscles loaded with the pH-sensitive dye 2', 7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein in the esterified form to study the effect of endothelin-1 (ET-1) on the activity of the Na(+)-independent Cl(-)-HCO(3)(-) exchanger. Exposure to...

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Veröffentlicht in:	Circulation research 2000-03, Vol.86 (6), p.622-627
Hauptverfasser:	de Hurtado, M C, Alvarez, B V, Ennis, I L, Cingolani, H E
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid - pharmacology Alkalies - metabolism Angiotensin II - pharmacology Animals Antiporters - antagonists & inhibitors Antiporters - metabolism Bicarbonates - metabolism Buffers Carbon Dioxide - metabolism Cats Chloride-Bicarbonate Antiporters Endothelin Receptor Antagonists Endothelins - physiology Hydrogen-Ion Concentration - drug effects Methylamines - pharmacology Myocardium - metabolism Oligopeptides - pharmacology Peptides, Cyclic - pharmacology Rats Receptor, Endothelin A Sodium - physiology
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Zusammenfassung:	Experiments were performed in isolated cat papillary muscles loaded with the pH-sensitive dye 2', 7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein in the esterified form to study the effect of endothelin-1 (ET-1) on the activity of the Na(+)-independent Cl(-)-HCO(3)(-) exchanger. Exposure to ET-1 (10 nmol/L) raised pH(i) by 0.13+/-0.03 U (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.86.6.622