5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-03, Vol.10 (5), p.461-464
Hauptverfasser:	Ryu, Chung-Kyu, Kang, Hye-Young, Lee, Sang Kook, Nam, Kyung Ae, Hong, Chang Yong, Ko, Won-Gil, Lee, Byung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - antagonists & inhibitors Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology General aspects HL-60 Cells Humans Medical sciences Pharmacology. Drug treatments Proto-Oncogene Proteins Thiazoles - chemical synthesis Thiazoles - pharmacology Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00014-7