Increase of endothelial nitric oxide synthase and endothelin-1 mRNA expression in human placenta during gestation

Objective: To investigate the maturation of the paracrine system’s endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), endothelin-1 (ET-1) and adrenomedullin (AM) in human placenta during the 2nd and 3rd trimester of pregnancy. Study design: Placental tissue from 14 healthy women with no...

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Veröffentlicht in:	European journal of obstetrics & gynecology and reproductive biology 2001-08, Vol.97 (2), p.163-167
Hauptverfasser:	Dötsch, Jörg, Hogen, Naemi, Nyúl, Zoltan, Hänze, Jörg, Knerr, Ina, Kirschbaum, Michael, Rascher, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Adult Biological and medical sciences Endothelin-1 Endothelin-1 - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Gestational Age Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Humans Mother. Fetoplacental unit. Mammary gland. Milk Nitric oxide synthase Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Peptides - genetics Placenta Placenta - chemistry Placenta - enzymology Placenta - metabolism Pregnancy Pregnancy. Parturition. Lactation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Vertebrates: reproduction
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Zusammenfassung:	Objective: To investigate the maturation of the paracrine system’s endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), endothelin-1 (ET-1) and adrenomedullin (AM) in human placenta during the 2nd and 3rd trimester of pregnancy. Study design: Placental tissue from 14 healthy women with normal pregnancy and from 13 patients giving birth to premature infants following premature labor was obtained. Messenger RNA expression was determined using quantitative TaqMan real-time PCR. Results: Placental eNOS/GAPDH and ET-1/GAPDH mRNA expression significantly increased as a function of gestational age ( r=0.63, P
ISSN:	0301-2115 1872-7654
DOI:	10.1016/S0301-2115(00)00532-7