Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

ABSTRACT—Recent studies provide increasing evidence that postnatal neovascularization involves bone marrow-derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in patients with coronary artery disease (CAD) is unclear at present. Therefore, we determined the number and fun...

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Veröffentlicht in:Circulation research 2001-07, Vol.89 (1), p.e1-e7
Hauptverfasser: Vasa, Mariuca, Fichtlscherer, Stephan, Aicher, Alexandra, Adler, Klaudia, Urbich, Carmen, Martin, Hans, Zeiher, Andreas M, Dimmeler, Stefanie
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Sprache:eng
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Zusammenfassung:ABSTRACT—Recent studies provide increasing evidence that postnatal neovascularization involves bone marrow-derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in patients with coronary artery disease (CAD) is unclear at present. Therefore, we determined the number and functional activity of EPCs in 45 patients with CAD and 15 healthy volunteers. The numbers of isolated EPCs and circulating CD34/kinase insert domain receptor (KDR)-positive precursor cells were significantly reduced in patients with CAD by ≈40% and 48%, respectively. To determine the influence of atherosclerotic risk factors, a risk factor score including age, sex, hypertension, diabetes, smoking, positive family history of CAD, and LDL cholesterol levels was used. The number of risk factors was significantly correlated with a reduction of EPC levels (R =−0.394, P =0.002) and CD34-/KDR-positive cells (R =−0.537, P
ISSN:0009-7330
1524-4571
DOI:10.1161/hh1301.093953