Novel C-ring analogues of 20(S)-camptothecin. Part 3 : Synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues

Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-02, Vol.10 (4), p.369-371
Hauptverfasser:	SUBRAHMANYAM, D, SARMA, V. M, VENKATESWARLU, A, SASTRY, T. V. R. S, SRINIVAS, A. S. S. V, KRISHNA, C. V, DEEVI, D. S, KUMAR, S. A, BABU, M. J, DAMODARAN, N. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Camptothecin - analogs & derivatives Camptothecin - chemical synthesis Camptothecin - pharmacology Chemotherapy Dose-Response Relationship, Drug Humans Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured - drug effects
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Beschreibung
Zusammenfassung:	Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00005-6