Cytochrome c release from mitochondria: all or nothing

Cytochrome c release from mitochondria: all or nothing

During the process of apoptosis, cytochrome c is released from mitochondria into the cytosol where it helps to activate the caspases, a family of killer proteases. The release of cytochrome c is a rapid, complete and kinetically invariant event.

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Bibliographische Detailangaben
Veröffentlicht in:Nature cell biology 2000-03, Vol.2 (3), p.E41-E43
Hauptverfasser: Martinou, Jean-Claude, Desagher, Solange, Antonsson, Bruno
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Biomedical and Life Sciences
Cancer Research
Caspases - metabolism
Cell Biology
Cell Line
Cell Membrane Permeability - physiology
Cytochrome
Cytochrome c
Cytochrome c Group - metabolism
Cytosol - enzymology
Developmental Biology
Evaluation
HeLa Cells
Humans
Intracellular Membranes - enzymology
Life Sciences
Mitochondria
Mitochondria - enzymology
Models, Biological
news-and-views
Physiological aspects
Stem Cells
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Beschreibung
Zusammenfassung:During the process of apoptosis, cytochrome c is released from mitochondria into the cytosol where it helps to activate the caspases, a family of killer proteases. The release of cytochrome c is a rapid, complete and kinetically invariant event.
ISSN:1465-7392
1476-4679
DOI:10.1038/35004069