Lower prolactin bioactivity in unmedicated schizophrenic patients

In previous work, prolactin (PRL) abnormalities of a lower bioassay (BA) to radioimmonoassay (RIA) ratio were found in schizophrenic patients. This line of research was extended in seven male patients with schizophrenia who were neuroleptic-free; seven male control subjects were also studied. PRL va...

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Veröffentlicht in:Psychiatry research 2001-07, Vol.102 (3), p.249-254
Hauptverfasser: Warner, M.Dhyanne, Walker, Ameae M, D'Souza, Deepak Cyril, Lee, David, Nasseri, Dorsa, Peabody, Cecilia A
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Sprache:eng
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Zusammenfassung:In previous work, prolactin (PRL) abnormalities of a lower bioassay (BA) to radioimmonoassay (RIA) ratio were found in schizophrenic patients. This line of research was extended in seven male patients with schizophrenia who were neuroleptic-free; seven male control subjects were also studied. PRL values were assessed by RIA and Nb 2 BA techniques. The schizophrenic group had a significantly lower PRL BA as compared to normal controls and a lower PRL ratio of BA/RIA. The lower ratio is consistent with an earlier finding and suggests that schizophrenic patients have different molecular forms of PRL than control subjects. This difference could be due to a disordered tuberoinfundibular dopamine system or the long-term effects of neuroleptic medications.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(01)00256-6