Lower prolactin bioactivity in unmedicated schizophrenic patients
In previous work, prolactin (PRL) abnormalities of a lower bioassay (BA) to radioimmonoassay (RIA) ratio were found in schizophrenic patients. This line of research was extended in seven male patients with schizophrenia who were neuroleptic-free; seven male control subjects were also studied. PRL va...
Gespeichert in:
Veröffentlicht in: | Psychiatry research 2001-07, Vol.102 (3), p.249-254 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | In previous work, prolactin (PRL) abnormalities of a lower bioassay (BA) to radioimmonoassay (RIA) ratio were found in schizophrenic patients. This line of research was extended in seven male patients with schizophrenia who were neuroleptic-free; seven male control subjects were also studied. PRL values were assessed by RIA and Nb
2 BA techniques. The schizophrenic group had a significantly lower PRL BA as compared to normal controls and a lower PRL ratio of BA/RIA. The lower ratio is consistent with an earlier finding and suggests that schizophrenic patients have different molecular forms of PRL than control subjects. This difference could be due to a disordered tuberoinfundibular dopamine system or the long-term effects of neuroleptic medications. |
---|---|
ISSN: | 0165-1781 1872-7123 |
DOI: | 10.1016/S0165-1781(01)00256-6 |