Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)

The two most abundant secreted isoforms of vascular endothelial growth factor A (VEGF(165) and VEGF(121)) are formed as a result of differential splicing of the VEGF-A gene. VEGF(165) and VEGF(121) share similar affinities at the isolated VEGF receptor (VEGFR)-2 but have been previously demonstrated...

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Veröffentlicht in:	The Journal of biological chemistry 2001-07, Vol.276 (27), p.25520-25531
Hauptverfasser:	Whitaker, G B, Limberg, B J, Rosenbaum, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Binding, Competitive Cells, Cultured COS Cells Electrophoresis, Polyacrylamide Gel Endothelial Growth Factors - metabolism Endothelium, Vascular - metabolism Humans Lymphokines - metabolism Macromolecular Substances Nerve Tissue Proteins - metabolism Neuropilin-1 Phosphorylation Placenta Growth Factor Pregnancy Proteins - metabolism Protein Binding Protein Conformation Receptor Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor Signal Transduction Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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