Inhibitory Effect of Herbal Medicines on Rotavirus Infectivity

The inhibitory effect of some traditional herbal medicines on the infectivity of rotavirus, which predominanthy occurs in sporadic diarrhea in infants and young children, was investigated. Among the 34 kinds of herbal medicines tested, the fruit of Citrus aurantium had the most potent inhibitory act...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/03/01, Vol.23(3), pp.356-358
Hauptverfasser:	KIM, Dong-Hyun, SONG, Mi-Jeong, BAE, Eun-Ah, HAN, Myung Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents antirotaviral activity Antiviral agents Biological and medical sciences Citrus aurantium General pharmacology herbal medicine hesperidin Medical sciences Microbial Sensitivity Tests neohesperidin Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Rotavirus - drug effects Rotavirus - pathogenicity Virulence - drug effects
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Beschreibung
Zusammenfassung:	The inhibitory effect of some traditional herbal medicines on the infectivity of rotavirus, which predominanthy occurs in sporadic diarrhea in infants and young children, was investigated. Among the 34 kinds of herbal medicines tested, the fruit of Citrus aurantium had the most potent inhibitory activity on rotavirus infection. The active components of the fruit of Citrus aurantium were neohesperidin and hesperidin. Their 50% inhibitory concentrations were 25 and 10 μM, respectively.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.23.356