Desaturation Function Does Not Decline after Menopause in Human Females

Desaturation Function Does Not Decline after Menopause in Human Females

Aging appears to decrease delta6-desaturase activity in males, but in females it is uncertain. delta6- and delta5-desaturase functions were investigated in pre- and post-menopausal women who were normoglycemic or had type 2 diabetes (2 x 2 factorial, n = 37). Subjects were compared for indicators of...

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Veröffentlicht in:Hormone and metabolic research 2000-01, Vol.32 (1), p.26-32
Hauptverfasser: Liu, Y. W., Medeiros, L. C., Revesz, E., O'Dorisio, T. M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aging
Blood Platelets - metabolism
C-Peptide - blood
Cholesterol Esters - metabolism
Diabetes Mellitus, Type 2 - enzymology
Diet
Fatty Acid Desaturases - metabolism
Fatty Acids - chemistry
Female
Humans
Insulin - blood
Linoleoyl-CoA Desaturase
Middle Aged
Obesity
Originals Clinical
Phospholipids - blood
Phospholipids - chemistry
Postmenopause - metabolism
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Zusammenfassung:Aging appears to decrease delta6-desaturase activity in males, but in females it is uncertain. delta6- and delta5-desaturase functions were investigated in pre- and post-menopausal women who were normoglycemic or had type 2 diabetes (2 x 2 factorial, n = 37). Subjects were compared for indicators of diabetic control, estrogen levels, fatty acid profiles and indices of delta6- and delta5-desaturase activity. Diet intakes that were compared to determine whether results were a function of dietary factors known to influence desaturase activity revealed no differences (P>0.05). Post-menopausal women with type 2 diabetes had more 18:2 n6 in serum phospholipids (P
ISSN:0018-5043
1439-4286
DOI:10.1055/s-2007-978581