Mechanism of Inhibition of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE) by a Statine-based Peptide

Inhibition of β-site amyloid precursor protein-cleaving enzyme by a statine-based inhibitor has been studied using steady state and stopped-flow methods. A slow onset rate of inhibition has been observed under steady state conditions, and aKi of 22 nm has been derived using progress curves analysis....

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (26), p.23790-23794
Hauptverfasser:	Marcinkeviciene, Jovita, Luo, Ying, Graciani, Nilsa R., Combs, Andrew P., Copeland, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Amino Acids - pharmacology Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - chemistry Aspartic Acid Endopeptidases - metabolism b-Site APP cleaving enzyme Endopeptidases Fluorescence Humans Kinetics Peptides - metabolism Peptides - pharmacology Protein Conformation statine
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