Postprandial Hyperlipidemia in Zucker Diabetic Fatty fa / fa Rats, an Animal Model of Type II Diabetes, and Its Amelioration by Acyl-CoA:Cholesterol Acyltransferase Inhibition

Postprandial hyperlipidemia (PH) is frequently observed in diabetic patients. We performed an oral fat-loading test in Zucker diabetic fatty (ZDF) fa / fa rats, a model for type II diabetes, to determine whether PH was induced in the rats. Post fat-loading changes in serum cholesterol and triglyceri...

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Veröffentlicht in:Japanese Journal of Pharmacology 2001, Vol.86(1), pp.127-129
Hauptverfasser: Fujinami, Koji, Kojima, Kazuhiro, Aragane, Katsumi, Kusunoki, Jun
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Sprache:eng
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Zusammenfassung:Postprandial hyperlipidemia (PH) is frequently observed in diabetic patients. We performed an oral fat-loading test in Zucker diabetic fatty (ZDF) fa / fa rats, a model for type II diabetes, to determine whether PH was induced in the rats. Post fat-loading changes in serum cholesterol and triglyceride levels were significantly greater in the fa / fa rats than those seen in their lean littermates and an acyl-CoA:choles-terol acyltransferase (ACAT) inhibitor significantly reduced these levels by 24% and 31%, respectively. Therefore, we confirmed that PH appeared in ZDF fa/fa rats by fat loading and ACAT inhibition may be a potential treatment for PH.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.86.127