Highly Efficient Ligands for Palladium-Catalyzed Asymmetric Alkylation of Ketone Enolates

Highly Efficient Ligands for Palladium-Catalyzed Asymmetric Alkylation of Ketone Enolates

Ferrocene-modified chiral pocket ligands have been studied in the palladium-catalyzed asymmetric alkylation of simple ketone enolates, in which (R,R,Sp,Sp)-1 containing two pairs of matched chiralities, central chirality and planar chirality, behaved very efficiently in this reaction and up to 95% e...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2001-01, Vol.3 (2), p.149-151
Hauptverfasser: You, Shu-Li, Hou, Xue-Long, Dai, Li-Xin, Zhu, Xia-Zhen
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Ferrocene-modified chiral pocket ligands have been studied in the palladium-catalyzed asymmetric alkylation of simple ketone enolates, in which (R,R,Sp,Sp)-1 containing two pairs of matched chiralities, central chirality and planar chirality, behaved very efficiently in this reaction and up to 95% ee value was achieved.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0067033