Identification and analysis of a third mouse Polycomb gene, MPc3

A new mouse Polycomb ( Pc) gene, MPc3, has been identified. The MPc3 protein contains the highly conserved chromodomain and carboxy-terminal COOH box of other known Pc proteins from diverse species. Like other Pc proteins, MPc3 physically interacts with the RING finger proteins RING1A and dinG/RING1...

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Veröffentlicht in:	Gene 2000-01, Vol.242 (1), p.31-40
Hauptverfasser:	Hemenway, Charles S., Halligan, Benjamin W., Gould, Grahame C.D., Levy, Laura S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Chromodomain Chromosome 11 Chromosome Mapping COOH box dinG/RING1B dinG/RING1B protein DNA - chemistry DNA - genetics DNA, Complementary - chemistry DNA, Complementary - genetics DNA-Binding Proteins - metabolism Embryo, Mammalian - metabolism Exons Gene Expression Regulation, Developmental In Situ Hybridization, Fluorescence Introns Mice Mice, Inbred Strains Mitochondrial Membrane Transport Proteins Molecular Sequence Data MPc3 gene MPc3 protein PcG protein complex Polycomb gene Polycomb Repressive Complex 1 Polycomb-Group Proteins Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism RING1A protein RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid Two-Hybrid System Techniques
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Beschreibung
Zusammenfassung:	A new mouse Polycomb ( Pc) gene, MPc3, has been identified. The MPc3 protein contains the highly conserved chromodomain and carboxy-terminal COOH box of other known Pc proteins from diverse species. Like other Pc proteins, MPc3 physically interacts with the RING finger proteins RING1A and dinG/RING1B. MPc3 maps to the distal arm of mouse chromosome 11 (11E2), a region that contains other known Pc genes in addition to several disease loci that may be linked to abnormal Pc gene function.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/S0378-1119(99)00540-5