Bombardolides: New Antifungal and Antibacterial γ-Lactones from the Coprophilous Fungus Bombardioidea anartia
Chemical studies of organic extracts from cultures of the coprophilous fungus Bombardioidea anartia have led to the discovery of bombardolides A--D (1--4), a series of new antifungal and antibacterial metabolites. Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isom...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2001-06, Vol.64 (6), p.809-812 |
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| container_issue | 6 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | HEIN, Sara M. GLOER, James B. KOSTER, Brenda MALLOCH, David |
| description | Chemical studies of organic extracts from cultures of the coprophilous fungus Bombardioidea anartia have led to the discovery of bombardolides A--D (1--4), a series of new antifungal and antibacterial metabolites. Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isomers. A new 3-substituted phenol (5) and the known compound asterriquinone B4 were also encountered. The structures of compounds 1--5 were determined by analysis of NMR and MS data. |
| doi_str_mv | 10.1021/np000617u |
| format | Article |
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Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isomers. A new 3-substituted phenol (5) and the known compound asterriquinone B4 were also encountered. 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Psychology</subject><subject>g-Lactones</subject><subject>Lactones - chemistry</subject><subject>Lactones - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Xylariales - chemistry</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1OwzAQhS0EoqWw4AIoC8Qu4EliO2EHFS0_FVBRiWU0dRww5Ke1EwE7tpyHe3AIToJFCyyRRhq9mW-eRo-QbaD7QAM4qGaUUg6iXSFdYAH1OQ3YKulS4KEfxjzqkA1rHxwU0oStkw5AFIBgQZfMj-tyiiarC50pe_j5-uZdqifvqGp03lZ3WHhYZd9yirJRRrvJx7s_cqKulPVyU5dec6-8fj0z9exeF3VrvYE7dW3prWvnjc4ITaNxk6zlWFi1tew9MhmcTPqn_uhqeNY_Gvk6pKzxE5pF8TQDkKEAqfJA8JgJRMkiyoTKOI-EUiDzIEbIESGJHSClZEkGQR72yN7C1r01b5Vt0lJbqYoCK-VeTAVNOOcA_4IQ09jFFjtwZwm201Jl6czoEs1L-hOmA3aXAFqJRW6wktr-cZSL0FWP-AtM20Y9_67RPKZuK1g6ub5JL0bjWzbsn6fj8AseyJRD</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>HEIN, Sara M.</creator><creator>GLOER, James B.</creator><creator>KOSTER, Brenda</creator><creator>MALLOCH, David</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Bombardolides: New Antifungal and Antibacterial γ-Lactones from the Coprophilous Fungus Bombardioidea anartia</title><author>HEIN, Sara M. ; GLOER, James B. ; KOSTER, Brenda ; MALLOCH, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i305t-90d48bd11c371cef276857aac54057ed6647ee1cf28a1faa198685ccc59d12f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - isolation & purification</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Bombardioidea anartia</topic><topic>bombardolides</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Deer</topic><topic>Feces - microbiology</topic><topic>Fundamental and applied biological sciences. 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Nat. Prod</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>64</volume><issue>6</issue><spage>809</spage><epage>812</epage><pages>809-812</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Chemical studies of organic extracts from cultures of the coprophilous fungus Bombardioidea anartia have led to the discovery of bombardolides A--D (1--4), a series of new antifungal and antibacterial metabolites. Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isomers. A new 3-substituted phenol (5) and the known compound asterriquinone B4 were also encountered. The structures of compounds 1--5 were determined by analysis of NMR and MS data.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>11421752</pmid><doi>10.1021/np000617u</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2001-06, Vol.64 (6), p.809-812 |
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| language | eng |
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| source | MEDLINE; ACS Journals: American Chemical Society Web Editions |
| subjects | Animals Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Bombardioidea anartia bombardolides Chromatography, High Pressure Liquid Deer Feces - microbiology Fundamental and applied biological sciences. Psychology g-Lactones Lactones - chemistry Lactones - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Spectrometry, Mass, Fast Atom Bombardment Xylariales - chemistry |
| title | Bombardolides: New Antifungal and Antibacterial γ-Lactones from the Coprophilous Fungus Bombardioidea anartia |
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