Bombardolides: New Antifungal and Antibacterial γ-Lactones from the Coprophilous Fungus Bombardioidea anartia

Chemical studies of organic extracts from cultures of the coprophilous fungus Bombardioidea anartia have led to the discovery of bombardolides A--D (1--4), a series of new antifungal and antibacterial metabolites. Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isom...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-06, Vol.64 (6), p.809-812
Hauptverfasser:	HEIN, Sara M., GLOER, James B., KOSTER, Brenda, MALLOCH, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Bombardioidea anartia bombardolides Chromatography, High Pressure Liquid Deer Feces - microbiology Fundamental and applied biological sciences. Psychology g-Lactones Lactones - chemistry Lactones - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Spectrometry, Mass, Fast Atom Bombardment Xylariales - chemistry
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Zusammenfassung:	Chemical studies of organic extracts from cultures of the coprophilous fungus Bombardioidea anartia have led to the discovery of bombardolides A--D (1--4), a series of new antifungal and antibacterial metabolites. Three of these metabolites (1--3) were obtained as inseparable pairs of geometric isomers. A new 3-substituted phenol (5) and the known compound asterriquinone B4 were also encountered. The structures of compounds 1--5 were determined by analysis of NMR and MS data.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000617u