Insulin receptors in the brain cortex of aging mice

The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As...

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Veröffentlicht in:	Mechanisms of ageing and development 2000-02, Vol.113 (3), p.227-232
Hauptverfasser:	Zaia, Annamaria, Piantanelli, Lucio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Animals Binding Sites Biological and medical sciences Brain cortex Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism Fundamental and applied biological sciences. Psychology Insulin - metabolism Insulin receptors Kinetics Mice Mice, Inbred BALB C Mice, Nude Mouse Receptor, Insulin - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging.
ISSN:	0047-6374 1872-6216
DOI:	10.1016/S0047-6374(99)00118-9