Steroidal Alkaloids from the Leaves of Sarcococca coriacea of Nepalese Origin

Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of S...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-06, Vol.64 (6), p.842-844
Hauptverfasser:	KALAUNI, Surya K., CHOUDHARY, M. Iqbal, SHAHEEN, Farzana, MANANDHAR, Mangala D., ATTA-UR-RAHMAN, GEWALI, Mohan B., KHALID, Asaad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Electrophorus General pharmacology Horses Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Nepal Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry Progesterone - analogs & derivatives Progesterone - chemistry Progesterone - pharmacology Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Zusammenfassung:	Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000466v