Increased microvessel density in malignant and borderline mammary phyllodes tumours

Increased microvessel density in malignant and borderline mammary phyllodes tumours Aims: Tumour vascularity is considered a prognostic indicator in breast carcinoma, but its utility in mammary phyllodes tumour has not been explored. The authors report the correlation between intratumoral microvessel density and the histological grade of phyllodes tumour. Methods and results: Forty cases of phyllodes tumour were reviewed for stromal cellularity, overgrowth, cytological pleomorphism, mitotic count and margin pattern. Using established criteria, these were diagnosed as benign (n=28), borderline (n=10) and malignant (n=2). Microvessel density was counted on CD31‐stained slides as the number of vessels per high power field. For benign phyllodes tumour, the range was 7–26.2 (mean 13.1); for borderline phyllodes tumour the range was 17.2–32.5 (mean 22.4); for malignant phyllodes tumour the range was 25.9–33.3 (mean 29.6). The difference between the benign and borderline groups was significant (P