The activation of B-Raf and Raf-1 after electroconvulsive shock in the rat hippocampus

We demonstrated that ECS activates the kinase activity of B-Raf and Raf-1 in the rat hippocampus. The activity was maximal at one minute after ECS and temporally coincided with the increased membrane translocation of Rafs and the reported activity of MAPK, but not with the phosphorylation of Rafs.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuropharmacology 2000-02, Vol.39 (4), p.703-706
Hauptverfasser:	Kang, Ung Gu, Jeon, Song Hee, Lee, Jong Eun, Joo, Yeon-Ho, Yi, Jung Seo, Park, Joo-Bae, Juhnn, Yong-Sung, Kim, Yong Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Raf B-Raf protein Biological and medical sciences Biological Transport Cell Membrane - metabolism Electroconvulsive shock Electroconvulsive therapy Electroshock Hippocampus Hippocampus - enzymology Hippocampus - metabolism Immunoblotting Male MAPK Medical sciences Phosphorylation Proto-Oncogene Proteins c-raf - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Raf-1 Raf-1 protein Rats Rats, Sprague-Dawley Treatments
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Beschreibung
Zusammenfassung:	We demonstrated that ECS activates the kinase activity of B-Raf and Raf-1 in the rat hippocampus. The activity was maximal at one minute after ECS and temporally coincided with the increased membrane translocation of Rafs and the reported activity of MAPK, but not with the phosphorylation of Rafs.
ISSN:	0028-3908 1873-7064
DOI:	10.1016/S0028-3908(99)00184-7