In vitro model for frontal sinus obliteration with bioactive glass S53P4
An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer...
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| Veröffentlicht in: | Journal of biomedical materials research 2000, Vol.53 (2), p.161-166 |
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| creator | Peltola, Matti J. Suonpää, Jouko T. K. Andersson, H. Määttänen, Heli S. Aitasalo, Kalle M. J. Yli-Urpo, Antti Laippala, Pekka J. |
| description | An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer containing trishydroxymethyl aminomethane citric acid (TRIS‐c.a) in standard conditions. The dissolution of silicon (Si) and phosphate (P) was detected with direct current plasma atom emission spectroscopy (DCP‐AES) monthly up to 6 months. The BG masses were scanned by computer tomography (CT) and the scans analyzed by Region of Interest (ROI) technique. Calcium phosphate (CaP)‐ and silica (Si)‐gel‐layers were studied by scanning electron microscopy (SEM) at 1, 3, and 6 months. Cumulative loss of Si and P was stronger in TRIS ‐c.a than in SBF (p < 0.0001), and it was higher with smaller than with larger granules in both solutions (p < 0.0001).This was shown correspondingly by the decrease in Hounsfield units (HU) by ROI analysis (p < 0.0001). In SBF‐soaked BG masses, the CaP‐layer occurred on the uppermost granules, and in TRIS‐c.a at 3–6 months, on the granules in the center and lower parts. The decrease of HU seems to reveal indirectly the resorption of BG. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 53: 161–166, 2000 |
| doi_str_mv | 10.1002/(SICI)1097-4636(2000)53:2<161::AID-JBM5>3.0.CO;2-3 |
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K. ; Andersson, H. ; Määttänen, Heli S. ; Aitasalo, Kalle M. J. ; Yli-Urpo, Antti ; Laippala, Pekka J.</creator><creatorcontrib>Peltola, Matti J. ; Suonpää, Jouko T. K. ; Andersson, H. ; Määttänen, Heli S. ; Aitasalo, Kalle M. J. ; Yli-Urpo, Antti ; Laippala, Pekka J.</creatorcontrib><description>An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer containing trishydroxymethyl aminomethane citric acid (TRIS‐c.a) in standard conditions. The dissolution of silicon (Si) and phosphate (P) was detected with direct current plasma atom emission spectroscopy (DCP‐AES) monthly up to 6 months. The BG masses were scanned by computer tomography (CT) and the scans analyzed by Region of Interest (ROI) technique. Calcium phosphate (CaP)‐ and silica (Si)‐gel‐layers were studied by scanning electron microscopy (SEM) at 1, 3, and 6 months. Cumulative loss of Si and P was stronger in TRIS ‐c.a than in SBF (p < 0.0001), and it was higher with smaller than with larger granules in both solutions (p < 0.0001).This was shown correspondingly by the decrease in Hounsfield units (HU) by ROI analysis (p < 0.0001). In SBF‐soaked BG masses, the CaP‐layer occurred on the uppermost granules, and in TRIS‐c.a at 3–6 months, on the granules in the center and lower parts. The decrease of HU seems to reveal indirectly the resorption of BG. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 53: 161–166, 2000</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/(SICI)1097-4636(2000)53:2<161::AID-JBM5>3.0.CO;2-3</identifier><identifier>PMID: 10713562</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>bioactive glass ; Biocompatibility ; Biological and medical sciences ; Body Fluids ; Bone Substitutes ; Calcium compounds ; Computer aided analysis ; Dissolution ; Electron Probe Microanalysis ; Emission spectroscopy ; Frontal Sinus - diagnostic imaging ; Frontal Sinus - surgery ; Frontal Sinusitis - diagnostic imaging ; Frontal Sinusitis - surgery ; Glass ; Humans ; in vitro model ; Indicators and Reagents ; Medical sciences ; Microscopy, Electron, Scanning ; Phosphates ; Physiological models ; region of interest technique ; Silicon ; sinus obliteration ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. 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K.</creatorcontrib><creatorcontrib>Andersson, H.</creatorcontrib><creatorcontrib>Määttänen, Heli S.</creatorcontrib><creatorcontrib>Aitasalo, Kalle M. J.</creatorcontrib><creatorcontrib>Yli-Urpo, Antti</creatorcontrib><creatorcontrib>Laippala, Pekka J.</creatorcontrib><title>In vitro model for frontal sinus obliteration with bioactive glass S53P4</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer containing trishydroxymethyl aminomethane citric acid (TRIS‐c.a) in standard conditions. The dissolution of silicon (Si) and phosphate (P) was detected with direct current plasma atom emission spectroscopy (DCP‐AES) monthly up to 6 months. The BG masses were scanned by computer tomography (CT) and the scans analyzed by Region of Interest (ROI) technique. Calcium phosphate (CaP)‐ and silica (Si)‐gel‐layers were studied by scanning electron microscopy (SEM) at 1, 3, and 6 months. Cumulative loss of Si and P was stronger in TRIS ‐c.a than in SBF (p < 0.0001), and it was higher with smaller than with larger granules in both solutions (p < 0.0001).This was shown correspondingly by the decrease in Hounsfield units (HU) by ROI analysis (p < 0.0001). In SBF‐soaked BG masses, the CaP‐layer occurred on the uppermost granules, and in TRIS‐c.a at 3–6 months, on the granules in the center and lower parts. The decrease of HU seems to reveal indirectly the resorption of BG. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 53: 161–166, 2000</description><subject>bioactive glass</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Body Fluids</subject><subject>Bone Substitutes</subject><subject>Calcium compounds</subject><subject>Computer aided analysis</subject><subject>Dissolution</subject><subject>Electron Probe Microanalysis</subject><subject>Emission spectroscopy</subject><subject>Frontal Sinus - diagnostic imaging</subject><subject>Frontal Sinus - surgery</subject><subject>Frontal Sinusitis - diagnostic imaging</subject><subject>Frontal Sinusitis - surgery</subject><subject>Glass</subject><subject>Humans</subject><subject>in vitro model</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Phosphates</subject><subject>Physiological models</subject><subject>region of interest technique</subject><subject>Silicon</subject><subject>sinus obliteration</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tomography, X-Ray Computed</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1v0zAUhiMEYmXwF5AvENouUo7jjyQFIa2BrUGFIjbE5ZHjOOCRJsNON_bvcWi1IYGAC8uy9fg9r_VE0YzClAIkzw5Oy6I8pJCnMZdMHiQAcCjYLHlBJZ3NjspX8Zv5W_GSTWFarJ4nMbsTTW7wu9EkhNA4Z8D3ogfen4fnec7o_WiPQkqZkMkkWpQdubSD68m6r01Lmt6RxvXdoFribbfxpK9aOxinBtt35MoOX0hle6UHe2nI51Z5T04Fe88fRvca1XrzaLfvRx-PX58Vi3i5OimLo2WseSZFTGktcl1pVYOosozpBPImrKySIjN5aqAxmlOgBlTNTMNNxkFWqQIOogn_2o-ebnMvXP9tY_yAa-u1aVvVmX7jMYVc5ILxf4JJKjnNxH-AlFMhpQjghy2oXe-9Mw1eOLtW7hop4GgMcTSGowIcFeBoDAXDBIMxxGAMR2PIELBYhWsWQh_vpm-qtal_idwqCsCTHaC8Vm3jVKetv-UYTWWe3pa7sq25_q3ZX4v9odfPcwiNt6HWD-b7TahyX1GmLBX46d0JLo55NudnS5yzH0H2yRs</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Peltola, Matti J.</creator><creator>Suonpää, Jouko T. K.</creator><creator>Andersson, H.</creator><creator>Määttänen, Heli S.</creator><creator>Aitasalo, Kalle M. J.</creator><creator>Yli-Urpo, Antti</creator><creator>Laippala, Pekka J.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>In vitro model for frontal sinus obliteration with bioactive glass S53P4</title><author>Peltola, Matti J. ; Suonpää, Jouko T. K. ; Andersson, H. ; Määttänen, Heli S. ; Aitasalo, Kalle M. J. ; Yli-Urpo, Antti ; Laippala, Pekka J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4865-11d59cbcad05b883c209f2098b658e97e0fec4101e0ad3ef4e8406b7a0405f463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>bioactive glass</topic><topic>Biocompatibility</topic><topic>Biological and medical sciences</topic><topic>Body Fluids</topic><topic>Bone Substitutes</topic><topic>Calcium compounds</topic><topic>Computer aided analysis</topic><topic>Dissolution</topic><topic>Electron Probe Microanalysis</topic><topic>Emission spectroscopy</topic><topic>Frontal Sinus - diagnostic imaging</topic><topic>Frontal Sinus - surgery</topic><topic>Frontal Sinusitis - diagnostic imaging</topic><topic>Frontal Sinusitis - surgery</topic><topic>Glass</topic><topic>Humans</topic><topic>in vitro model</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Phosphates</topic><topic>Physiological models</topic><topic>region of interest technique</topic><topic>Silicon</topic><topic>sinus obliteration</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Tomography, X-Ray Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Peltola, Matti J.</creatorcontrib><creatorcontrib>Suonpää, Jouko T. K.</creatorcontrib><creatorcontrib>Andersson, H.</creatorcontrib><creatorcontrib>Määttänen, Heli S.</creatorcontrib><creatorcontrib>Aitasalo, Kalle M. J.</creatorcontrib><creatorcontrib>Yli-Urpo, Antti</creatorcontrib><creatorcontrib>Laippala, Pekka J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peltola, Matti J.</au><au>Suonpää, Jouko T. K.</au><au>Andersson, H.</au><au>Määttänen, Heli S.</au><au>Aitasalo, Kalle M. J.</au><au>Yli-Urpo, Antti</au><au>Laippala, Pekka J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro model for frontal sinus obliteration with bioactive glass S53P4</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2000</date><risdate>2000</risdate><volume>53</volume><issue>2</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer containing trishydroxymethyl aminomethane citric acid (TRIS‐c.a) in standard conditions. The dissolution of silicon (Si) and phosphate (P) was detected with direct current plasma atom emission spectroscopy (DCP‐AES) monthly up to 6 months. The BG masses were scanned by computer tomography (CT) and the scans analyzed by Region of Interest (ROI) technique. Calcium phosphate (CaP)‐ and silica (Si)‐gel‐layers were studied by scanning electron microscopy (SEM) at 1, 3, and 6 months. Cumulative loss of Si and P was stronger in TRIS ‐c.a than in SBF (p < 0.0001), and it was higher with smaller than with larger granules in both solutions (p < 0.0001).This was shown correspondingly by the decrease in Hounsfield units (HU) by ROI analysis (p < 0.0001). In SBF‐soaked BG masses, the CaP‐layer occurred on the uppermost granules, and in TRIS‐c.a at 3–6 months, on the granules in the center and lower parts. The decrease of HU seems to reveal indirectly the resorption of BG. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 53: 161–166, 2000</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10713562</pmid><doi>10.1002/(SICI)1097-4636(2000)53:2<161::AID-JBM5>3.0.CO;2-3</doi><tpages>6</tpages></addata></record> |
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| subjects | bioactive glass Biocompatibility Biological and medical sciences Body Fluids Bone Substitutes Calcium compounds Computer aided analysis Dissolution Electron Probe Microanalysis Emission spectroscopy Frontal Sinus - diagnostic imaging Frontal Sinus - surgery Frontal Sinusitis - diagnostic imaging Frontal Sinusitis - surgery Glass Humans in vitro model Indicators and Reagents Medical sciences Microscopy, Electron, Scanning Phosphates Physiological models region of interest technique Silicon sinus obliteration Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tomography, X-Ray Computed |
| title | In vitro model for frontal sinus obliteration with bioactive glass S53P4 |
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