In vitro model for frontal sinus obliteration with bioactive glass S53P4

An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer...

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Veröffentlicht in:Journal of biomedical materials research 2000, Vol.53 (2), p.161-166
Hauptverfasser: Peltola, Matti J., Suonpää, Jouko T. K., Andersson, H., Määttänen, Heli S., Aitasalo, Kalle M. J., Yli-Urpo, Antti, Laippala, Pekka J.
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Sprache:eng
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Zusammenfassung:An in vitro model was used to investigate the behavior of a massive frontal sinus obliteration with bioactive glass S53P4 (BG) for clinical purposes. Two sizes of granules (0.63–0.8 mm or 0.8–1.0 mm) in 16 separate BG amounts, weight 25 g, were tested both in simulated body fluid (SBF) and a buffer containing trishydroxymethyl aminomethane citric acid (TRIS‐c.a) in standard conditions. The dissolution of silicon (Si) and phosphate (P) was detected with direct current plasma atom emission spectroscopy (DCP‐AES) monthly up to 6 months. The BG masses were scanned by computer tomography (CT) and the scans analyzed by Region of Interest (ROI) technique. Calcium phosphate (CaP)‐ and silica (Si)‐gel‐layers were studied by scanning electron microscopy (SEM) at 1, 3, and 6 months. Cumulative loss of Si and P was stronger in TRIS ‐c.a than in SBF (p < 0.0001), and it was higher with smaller than with larger granules in both solutions (p < 0.0001).This was shown correspondingly by the decrease in Hounsfield units (HU) by ROI analysis (p < 0.0001). In SBF‐soaked BG masses, the CaP‐layer occurred on the uppermost granules, and in TRIS‐c.a at 3–6 months, on the granules in the center and lower parts. The decrease of HU seems to reveal indirectly the resorption of BG. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 53: 161–166, 2000
ISSN:0021-9304
1097-4636
DOI:10.1002/(SICI)1097-4636(2000)53:2<161::AID-JBM5>3.0.CO;2-3