P2Y Receptor Regulation of PAI-1 Expression in Vascular Smooth Muscle Cells

ABSTRACTP2Y-type purine and pyrimidine nucleotide receptors play important roles in the regulation of vascular hemostasis. In this article, the regulation of plasminogen activator inhibitor-1 (PAI-1) expression in rat aortic smooth muscle cells (RASMCs) by adenine and uridine nucleotides was examine...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2000-03, Vol.20 (3), p.866-873
Hauptverfasser:	Bouchie, Julie L, Chen, Hong-Chi, Carney, Rebbeca, Bagot, J Courtney, Wilden, Peter A, Feener, Edward P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Angiotensin II - pharmacology Animals Biological and medical sciences Blood vessels and receptors Blotting, Western Cells, Cultured Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression - physiology Indoles - pharmacology Maleimides - pharmacology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - chemistry Muscle, Smooth, Vascular - enzymology Phosphorylation Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P2 - analysis Receptors, Purinergic P2 - genetics Receptors, Purinergic P2Y2 RNA, Messenger - analysis Thionucleotides - pharmacology Uridine Diphosphate - pharmacology Uridine Triphosphate - pharmacology Vasoconstrictor Agents - pharmacology Vertebrates: cardiovascular system
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Zusammenfassung:	ABSTRACTP2Y-type purine and pyrimidine nucleotide receptors play important roles in the regulation of vascular hemostasis. In this article, the regulation of plasminogen activator inhibitor-1 (PAI-1) expression in rat aortic smooth muscle cells (RASMCs) by adenine and uridine nucleotides was examined and compared. Northern analysis revealed that RASMCs express multiple P2Y receptor subtypes, including P2Y1, P2Y2, and P2Y6. Treatment of RASMCs with UTP increased PAI-1 mRNA expression and extracellular PAI-1 protein levels by 21-fold (P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.atv.20.3.866