Symptom pathogenesis during acute influenza: Interleukin-6 and Other cytokine responses

In experimental human influenza infection initiated by nasal inoculation, the magnitude of viral replication, fever, and symptoms correlate with nasopharyngeal lavage fluid levels of various cytokines. Our aim was to assess these relationships in patients with naturally occurring acute influenza. Pa...

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Veröffentlicht in:Journal of medical virology 2001-07, Vol.64 (3), p.262-268
Hauptverfasser: Kaiser, Laurent, Fritz, R. Scott, Straus, Stephen E., Gubareva, Larisa, Hayden, Frederick G.
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Sprache:eng
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Zusammenfassung:In experimental human influenza infection initiated by nasal inoculation, the magnitude of viral replication, fever, and symptoms correlate with nasopharyngeal lavage fluid levels of various cytokines. Our aim was to assess these relationships in patients with naturally occurring acute influenza. Patients with culture‐positive influenza illness of less than 36 hr of duration were studied. Nasopharyngeal washing were collected at enrollment and on Day 2, 4, 6 and 8 for quantitative virus isolation and IL‐6, TNF‐α, INF‐α, INF‐γ and IL‐10 determinations. Blood samples collected at entry and on Day 2 and 6 were processed to assess plasma cytokines and circulating influenza RNA. Patients received either oseltamivir or placebo for 5 days. We assessed the correlation between nasopharyngeal lavage fluid or blood levels of cytokines before treatment and viral titers, symptom severity and fever. Sixteen adult subjects (median age of 22 years) were studied. In this small group of patients no significant differences between placebo and oseltamivir patients were found in viral replication or measures of cytokines. Thus the data for all 16 subjects were pooled for analysis. At entry, influenza A viruses were cultured from nasopharyngeal washes at a median titer of 4.8 log10TCID50/ml of wash. Viral titers correlated positively with symptom score (P = 0.006) and temperature values (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.1045