The role of ABC transporters in antibiotic-producing organisms: drug secretion and resistance mechanisms

The role of ABC transporters in antibiotic-producing organisms: drug secretion and resistance mechanisms

Knowledge about biosynthetic gene clusters from antibiotic-producing actinomycetes is continuously increasing and the presence of an ABC transporter system is a fairly general phenomenon in most of these clusters. These transporters are involved in the secretion of the antibiotic through the cell me...

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Veröffentlicht in:Research in microbiology 2001-04, Vol.152 (3), p.341-350
Hauptverfasser: Méndez, Carmen, Salas, José A
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetaceae - chemistry
Actinomycetaceae - genetics
Actinomycetaceae - metabolism
Amino Acid Sequence
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - metabolism
antibiotics
antitumoral agents
ATP-Binding Cassette Transporters - physiology
Drug Resistance, Microbial
macrolide
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid
streptomycetes
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Beschreibung
Zusammenfassung:Knowledge about biosynthetic gene clusters from antibiotic-producing actinomycetes is continuously increasing and the presence of an ABC transporter system is a fairly general phenomenon in most of these clusters. These transporters are involved in the secretion of the antibiotic through the cell membrane and also contribute to self resistance to the produced antibiotic.
ISSN:0923-2508
1769-7123
DOI:10.1016/S0923-2508(01)01205-0