Aromatase and Sulfatase Inhibitors from Lepiota americana

Abstract From an edible mushroom LEPIOTA AMERICANA Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC 50 = 5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC 50 = 0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfata...

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Veröffentlicht in:	Planta medica 2000-02, Vol.66 (1), p.78-79
Hauptverfasser:	Kim, Dong-Seon, Jeong, Hyeh-Jean, Bhat, Krishna P. L., Park, So-Young, Kang, Soo-Hyon, Yoo, Eun-Hwa, Lee, Minna, Lee, Hang-Woo, Krueger, Robert J., Kim, Darrick S. H. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Aromatase Inhibitors Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Ergosterol - analogs & derivatives Ergosterol - chemistry Ergosterol - isolation & purification Ergosterol - pharmacology General pharmacology Letter Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Oxazines - chemistry Oxazines - isolation & purification Oxazines - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sulfatases - antagonists & inhibitors
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Zusammenfassung:	Abstract From an edible mushroom LEPIOTA AMERICANA Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC 50 = 5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC 50 = 0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3β-hydroxy-5,8-epidioxyergosta- 6,22-diene active against aromatase.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-0029-1243115