Technical report: chronic and acute intracochlear infusion in rodents

As a follow-up to the Brown et al., 1993 technique, we have made several improvements to the micro-cannula, osmotic pump procedure, enabling chronic intracochlear infusions while maintaining hearing. In addition, acute bolus injection techniques are briefly described in guinea pig, rat and mouse.

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Bibliographische Detailangaben
Veröffentlicht in:	Hearing research 2000-02, Vol.140 (1), p.212-215
Hauptverfasser:	Prieskorn, Diane M, Miller, Josef M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Auditory Threshold - drug effects Biological and medical sciences Bolus injection Cochlea - drug effects Cochlea - physiology Drug Delivery Systems - instrumentation Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Equipment Design Evoked Potentials, Auditory, Brain Stem - drug effects Fundamental and applied biological sciences. Psychology Guinea Pigs Hearing Infusion Pumps, Implantable Intracochlear infusion Mice Osmotic pump Rats Rodent Saline Solution, Hypertonic - administration & dosage Scala Tympani - drug effects Scala Tympani - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	As a follow-up to the Brown et al., 1993 technique, we have made several improvements to the micro-cannula, osmotic pump procedure, enabling chronic intracochlear infusions while maintaining hearing. In addition, acute bolus injection techniques are briefly described in guinea pig, rat and mouse.
ISSN:	0378-5955 1878-5891
DOI:	10.1016/S0378-5955(99)00193-8