Synthesis of immunoreagents for detection of deoxypyrrololine, a cross-link of bone collagen

Two immunogens (5,6) and two probes (fluorescent 7 and chemiluminescent 8) were prepared from benzyl ester (-)-10. These immunoreagents (5,6 and 7,8) are useful for detection of collagen cross-link (+)-deoxypyrrololine (Dpl, 4), and for development of assays for osteoporosis.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-02, Vol.10 (3), p.269-271
Hauptverfasser:	ADAMCZYK, M, JOHNSON, D. D, REDDY, R. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Biological and medical sciences Collagen - chemistry Fluorescence Polarization Immunoassay Humans Imidazoles - analysis Indicators and Reagents - chemical synthesis Investigative techniques, diagnostic techniques (general aspects) Luminescent Measurements Medical sciences Molecular Probes Osteoarticular system. Muscles Osteoporosis - diagnosis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
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Beschreibung
Zusammenfassung:	Two immunogens (5,6) and two probes (fluorescent 7 and chemiluminescent 8) were prepared from benzyl ester (-)-10. These immunoreagents (5,6 and 7,8) are useful for detection of collagen cross-link (+)-deoxypyrrololine (Dpl, 4), and for development of assays for osteoporosis.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00682-4