Discovery of the Ceruloplasmin Homologue Hephaestin: New Insight into the Copper/Iron Connection

Discovery of the Ceruloplasmin Homologue Hephaestin: New Insight into the Copper/Iron Connection

Approximately 75 years ago Hart and colleagues discovered that copper deficiency impaired mammalian iron metabolism. Discovery of hephaestin identifies a critical new component of the copper and iron connection in mammals. Hephaestin appears to be a multicopper oxidase required for efficient export...

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Veröffentlicht in:Nutrition reviews 2000-01, Vol.58 (1), p.22-26
1. Verfasser: Eisenstein, Richard S.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Ceruloplasmin - metabolism
Copper
Copper - deficiency
Copper - metabolism
Excretory system
Fundamental and applied biological sciences. Psychology
Humans
Intestinal Absorption
Intestine. Mesentery
Iron
Iron - metabolism
Membrane Proteins - metabolism
Nutrition
Vertebrates: digestive system
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Beschreibung
Zusammenfassung:Approximately 75 years ago Hart and colleagues discovered that copper deficiency impaired mammalian iron metabolism. Discovery of hephaestin identifies a critical new component of the copper and iron connection in mammals. Hephaestin appears to be a multicopper oxidase required for efficient export of iron from the intestine.
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.2000.tb01821.x