Synthesis of New Cationic Lipids from an Unsaturated Glycoside Scaffold

Synthesis of New Cationic Lipids from an Unsaturated Glycoside Scaffold

We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicoch...

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Veröffentlicht in:Organic letters 2001-06, Vol.3 (12), p.1893-1896
Hauptverfasser: Herscovici, Jean, Egron, Marie José, Quenot, Alain, Leclercq, Françoise, Leforestier, Nicolas, Mignet, Nathalie, Wetzer, Barbara, Scherman, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Cations
DNA - chemistry
Glycosides - chemistry
Lipids - chemical synthesis
Molecular Conformation
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Zusammenfassung:We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0159423