California ground squirrel ( Spermophilus beecheyi) blood sera inhibits crotalid venom proteolytic activity

Some California ground squirrels ( Spermophilus beecheyi) show limited necrosis following envenomation by northern Pacific rattlesnakes ( Crotalus viridis oreganus). This study demonstrates that S. beecheyi blood sera inhibits venom proteases. Sera from rattlesnake-abundant habitats inhibited C. v....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicon (Oxford) 2000-05, Vol.38 (5), p.713-721
Hauptverfasser:	Biardi, James E, Coss, Richard G, Smith, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal and plant ecology Animal, plant and microbial ecology Animals Antivenins - physiology Autoecology Biological and medical sciences California Crotalid Venoms - enzymology Crotalus atrox Crotalus viridis oreganus Culture Media Fundamental and applied biological sciences. Psychology Gelatinases - antagonists & inhibitors Gelatinases - metabolism Mammalia Sciuridae - blood Species Specificity Spermophilus beecheyi Tissue Inhibitor of Metalloproteinases - physiology Vertebrata
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Some California ground squirrels ( Spermophilus beecheyi) show limited necrosis following envenomation by northern Pacific rattlesnakes ( Crotalus viridis oreganus). This study demonstrates that S. beecheyi blood sera inhibits venom proteases. Sera from rattlesnake-abundant habitats inhibited C. v. oreganus venom more effectively than venom from two allopatric rattlesnake species, C. v. viridis and C. atrox, suggesting evolutionary specialization. The pattern of inhibition among squirrel populations corresponds best with history of rattlesnake predation, in contrast to current rattlesnake density.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/S0041-0101(99)00179-8