Dolastatin 3 and Two Novel Cyclic Peptides from a Palauan Collection of Lyngbya majuscula

A collection of Lyngbya majuscula from Palau contained the peptides dolastatin 3 (1), homodolastatin 3 (2), and kororamide (3), together with aplysiatoxin (4), debromoaplysiatoxin (5), and oscillatoxin A (6). The structures of the new peptides homodolastatin 3 (2) and kororamide (3) were determined...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-02, Vol.63 (2), p.279-282
Hauptverfasser:	MITCHELL, Scott S., FAULKNER, D. John, RUBINS, Kathleen, BUSHMAN, Frederic D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acids - analysis Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Depsipeptides Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry General aspects HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - isolation & purification Magnetic Resonance Spectroscopy Mass Spectrometry Microbiology Molecular Conformation Palau Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Zusammenfassung:	A collection of Lyngbya majuscula from Palau contained the peptides dolastatin 3 (1), homodolastatin 3 (2), and kororamide (3), together with aplysiatoxin (4), debromoaplysiatoxin (5), and oscillatoxin A (6). The structures of the new peptides homodolastatin 3 (2) and kororamide (3) were determined by interpretation of spectroscopic data and chemical degradation.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np990353f