Trypanosome and Animal Lanosterol Synthases Use Different Catalytic Motifs

Trypanosome and Animal Lanosterol Synthases Use Different Catalytic Motifs

Animals, fungi, and some protozoa convert oxidosqualene to lanosterol in the ring-forming reaction in sterol biosynthesis. The Trypanosoma cruzi lanosterol synthase has now been cloned. The sequence shares with the T. brucei lanosterol synthase a tyrosine substitution for the catalytically important...

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Veröffentlicht in:Organic letters 2001-06, Vol.3 (12), p.1957-1960
Hauptverfasser: Joubert, Bridget M, Buckner, Frederick S, Matsuda, Seiichi P. T
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Motifs
Amino Acid Sequence
Animals
Catalytic Domain
Humans
Intramolecular Transferases - metabolism
Molecular Sequence Data
Sequence Homology, Amino Acid
Trypanosoma cruzi - enzymology
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Zusammenfassung:Animals, fungi, and some protozoa convert oxidosqualene to lanosterol in the ring-forming reaction in sterol biosynthesis. The Trypanosoma cruzi lanosterol synthase has now been cloned. The sequence shares with the T. brucei lanosterol synthase a tyrosine substitution for the catalytically important active-site threonine found in animal and fungal lanosterol synthases.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0160506