Cell permeability as a parameter for lead generation in the protein Tyrosine kinase inhibition field

Based on the inverse relationship between polar surface area and cell permeability and capitalizing on the properties of pyrrolopyrimidines 1 as protein tyrosine kinase inhibitors, pyrrolopyridones 2 were designed and synthesized as potential leads for the development of novel inhibitors with improved cell permeability properties. Capitalizing on the properties of the protein tyrosine kinase inhibitors 1, pyrrolopyridones 2 were designed and synthesized as potential leads for the development of novel compounds with improved cell permeability properties.