Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on-line configurations for high-throughput analysis of acidic and basic drugs in rat plasma

Several configurations using 6‐ and 10‐port switching valves were studied for high flow, on‐line extraction of rat plasma coupled to an electrospray triple quadrupole mass spectrometer. Each plasma sample was diluted 1:1 with an aqueous internal standard solution. The sample was injected into a 2.1 ...

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Veröffentlicht in:Rapid communications in mass spectrometry 2001-01, Vol.15 (13), p.1075-1083
Hauptverfasser: Mallet, Claude R., Mazzeo, Jeff R., Neue, Uwe
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Sprache:eng
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