Hierarchical logistic regression models for clustered binary outcomes in studies of IVF-ET
Objective: To describe a hierarchical logistic regression model for clustered binary data, apply it to data from a study on the effect of hydrosalpinx on embryo implantation, and compare the results with analyses that do not account for clustering. Design: Observational study. Setting: Academic rese...
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Veröffentlicht in: | Fertility and sterility 2000-03, Vol.73 (3), p.575-581 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objective: To describe a hierarchical logistic regression model for clustered binary data, apply it to data from a study on the effect of hydrosalpinx on embryo implantation, and compare the results with analyses that do not account for clustering.
Design: Observational study.
Setting: Academic research environment.
Patient(s): Women undergoing IVF-ET for tubal disease.
Main Outcome Measure(s): Odds of per embryo implantation.
Result(s): Although regression estimates are largely similar between the models, the hierarchical model properly reflects the added variation due to clustering. Standard errors are higher, confidence intervals are wider, and
P values indicate fewer “statistically significant” effects.
Conclusion(s): Ignoring important sources of variation in any analysis can lead to incorrect confidence intervals and
P values. In studies of IVF-ET, where clustered data are common, unexplained heterogeneity can be substantial. In this setting, hierarchical logistic regression is an appropriate alternative to standard logistic regression. |
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ISSN: | 0015-0282 1556-5653 |
DOI: | 10.1016/S0015-0282(99)00577-4 |