Expression of IL-17 mRNA in Ovarian Cancer

IL-17 is considered as a proinflammatory cytokine. We have demonstrated IL-17 is an angiogenic factor and promotes tumor growth in murine tumor models. In this report, we investigated the expression of IL-17 mRNA by RT-PCR and the relationship between IL-17 expression and microvascular density in ov...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-04, Vol.282 (3), p.735-738
Hauptverfasser:	Kato, Takeshi, Furumoto, Hiroyuki, Ogura, Tomoko, Onishi, Yasuyo, Irahara, Minoru, Yamano, Shuji, Kamada, Masaharu, Aono, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Base Sequence DNA Primers - genetics Female Gene Expression Regulation, Neoplastic Humans IL-17 interleukin 17 Interleukin-17 - genetics Microcirculation - pathology mRNA Neovascularization, Pathologic - genetics ovarian cancer Ovarian Neoplasms - blood supply Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism
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Zusammenfassung:	IL-17 is considered as a proinflammatory cytokine. We have demonstrated IL-17 is an angiogenic factor and promotes tumor growth in murine tumor models. In this report, we investigated the expression of IL-17 mRNA by RT-PCR and the relationship between IL-17 expression and microvascular density in ovarian cancer. IL-17 mRNA was expressed in 11 (64.7%) of 17 ovarian cancer. And the average number of blood vessels observed in IL-17 positive tumors (173.4 ± 55.1/mm2) was significantly higher than that in negative tumors (107.7 ± 57.8/mm2). These results indicated IL-17 is expressed in a considerable proportion of ovarian cancer and promotes tumor angiogenesis. There was no significant relationship between IL-17 expression and clinicopathologic parameters.
ISSN:	0006-291X 1090-2104
DOI:	10.1006/bbrc.2001.4618