Cernuosides A and B, two sucrase inhibitors from Pulsatilla cernua

Two oleanane-type oligoglycosides, cernuosides A (1) and B (2), were isolated from the roots of Pulsatilla cernua (Ranunculaceae). Structure elucidation was accomplished by 1D and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, and ROESY) methods, FABMS, and hydrolysis. Both compounds showed moderate activity...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-02, Vol.63 (2), p.276-278
Hauptverfasser:	Zhang, Q, Ye, W, Yan, X, Zhu, G, Che, C.T, Zhao, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbohydrate Sequence chemical constituents of plants chemical structure China enzyme inhibitors Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology glycosides Glycosides - isolation & purification Glycosides - pharmacology Hydrolysis Intestine, Small - drug effects Intestine, Small - enzymology Magnetic Resonance Spectroscopy Medical sciences medicinal plants Molecular Sequence Data Oleanolic Acid - analogs & derivatives Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry pulsatilla cernua Rats roots spectral analysis Spectrometry, Mass, Fast Atom Bombardment Sucrase - antagonists & inhibitors sucrose alpha-glucosidase
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Zusammenfassung:	Two oleanane-type oligoglycosides, cernuosides A (1) and B (2), were isolated from the roots of Pulsatilla cernua (Ranunculaceae). Structure elucidation was accomplished by 1D and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, and ROESY) methods, FABMS, and hydrolysis. Both compounds showed moderate activity against sucrase.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np990207+