Cell Transplantation as a Treatment for Retinal Disease

Cell Transplantation as a Treatment for Retinal Disease

It has been shown that photoreceptor degeneration can be limited in experimental animals by transplantation of fresh RPE to the subretinal space. There is also evidence that retinal cell transplants can be used to reconstruct retinal circuitry in dystrophic animals. Here we describe and review recen...

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Veröffentlicht in:Progress in retinal and eye research 2001-07, Vol.20 (4), p.415-449
Hauptverfasser: Lund, R.D, Kwan, A.S.L, Keegan, D.J, Sauvé, Y, Coffey, P.J, Lawrence, J.M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Survival
Cell Transplantation - methods
Humans
Pigment Epithelium of Eye - cytology
Retina - cytology
Retinal Degeneration - surgery
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Zusammenfassung:It has been shown that photoreceptor degeneration can be limited in experimental animals by transplantation of fresh RPE to the subretinal space. There is also evidence that retinal cell transplants can be used to reconstruct retinal circuitry in dystrophic animals. Here we describe and review recent developments that highlight the necessary steps that should be taken prior to embarking on clinical trials in humans.
ISSN:1350-9462
1873-1635
DOI:10.1016/S1350-9462(01)00003-9