Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different di...
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| Veröffentlicht in: | Journal of Chromatography A 2001-05, Vol.918 (2), p.319-324 |
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| container_end_page | 324 |
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| container_title | Journal of Chromatography A |
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| creator | Grahek, Rok Milivojevič, Dušan Bastarda, Andrej Kračun, Matjaž |
| description | The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different displacers were successfully used. Up to 0.14 g of raw sample per gram of stationary phase was loaded on a column packed with silica-based octadecyl phase. Crude substances from 85 to 88% chromatographic purity were purified and at least 99.5% purity was achieved. |
| doi_str_mv | 10.1016/S0021-9673(01)00767-1 |
| format | Article |
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Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Pravastatin</topic><topic>Pravastatin - isolation & purification</topic><topic>Simvastatin</topic><topic>Simvastatin - isolation & purification</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grahek, Rok</creatorcontrib><creatorcontrib>Milivojevič, Dušan</creatorcontrib><creatorcontrib>Bastarda, Andrej</creatorcontrib><creatorcontrib>Kračun, Matjaž</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grahek, Rok</au><au>Milivojevič, Dušan</au><au>Bastarda, Andrej</au><au>Kračun, Matjaž</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2001-05-25</date><risdate>2001</risdate><volume>918</volume><issue>2</issue><spage>319</spage><epage>324</epage><pages>319-324</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. 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| ispartof | Journal of Chromatography A, 2001-05, Vol.918 (2), p.319-324 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Chromatography, High Pressure Liquid - methods Enzyme inhibitors General pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - isolation & purification Lovastatin Lovastatin - analogs & derivatives Lovastatin - isolation & purification Medical sciences Mevastatin Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pravastatin Pravastatin - isolation & purification Simvastatin Simvastatin - isolation & purification Spectrophotometry, Ultraviolet |
| title | Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors |
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