Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different di...

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Veröffentlicht in:Journal of Chromatography A 2001-05, Vol.918 (2), p.319-324
Hauptverfasser: Grahek, Rok, Milivojevič, Dušan, Bastarda, Andrej, Kračun, Matjaž
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Sprache:eng
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Zusammenfassung:The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different displacers were successfully used. Up to 0.14 g of raw sample per gram of stationary phase was loaded on a column packed with silica-based octadecyl phase. Crude substances from 85 to 88% chromatographic purity were purified and at least 99.5% purity was achieved.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)00767-1