Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different di...
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Veröffentlicht in: | Journal of Chromatography A 2001-05, Vol.918 (2), p.319-324 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The purification of pravastatin, simvastatin and lovastatin in the sodium salt or lactone form and of mevastatin in the lactone form by reversed-phase displacement chromatography is presented. The mobile phases consisted of water or mixtures of water–methanol and water–acetonitrile. Six different displacers were successfully used. Up to 0.14 g of raw sample per gram of stationary phase was loaded on a column packed with silica-based octadecyl phase. Crude substances from 85 to 88% chromatographic purity were purified and at least 99.5% purity was achieved. |
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ISSN: | 0021-9673 |
DOI: | 10.1016/S0021-9673(01)00767-1 |