Usefulness of route of transmission, absolute CD8+ T-cell counts, and levels of serum tumor necrosis factor alpha as predictors of survival of HIV-1-infected patients with very low CD4+ T-cell counts

Potential cofactors of survival in HIV-1-infected patients with CD4+ T-cell counts of < or = 100 cells/microl were investigated. All 132 patients with CD4+ T-cell counts of < or = 100 cells/microl were selected from 416 patients included in an antiretroviral therapy cohort (1989-1999). Fifty o...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 2001-04, Vol.20 (4), p.253-259
Hauptverfasser:	MACIAS, J, LEAL, M, DELGADO, J, PINEDA, J. A, MUNOZ, J, RELIMPIO, F, RUBIO, A, REY, C, LISSEN, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - mortality Acquired Immunodeficiency Syndrome - transmission Adolescent Adult AIDS Antiretroviral agents Antiretroviral drugs Biological and medical sciences CD4 antigen CD4 Lymphocyte Count CD8 antigen CD8-Positive T-Lymphocytes Cells Child Disease transmission Drug therapy Enzymes Female Hepatitis C HIV HIV-1 Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immune system Immunoassay Infections Infectious diseases Laboratories Lymphocyte Count Male Medical prognosis Medical sciences Middle Aged Polymerase chain reaction Proteinase inhibitors Sexually transmitted diseases STD Survival Tumor Necrosis Factor-alpha - analysis Tumor necrosis factor-TNF Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral infections
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Zusammenfassung:	Potential cofactors of survival in HIV-1-infected patients with CD4+ T-cell counts of < or = 100 cells/microl were investigated. All 132 patients with CD4+ T-cell counts of < or = 100 cells/microl were selected from 416 patients included in an antiretroviral therapy cohort (1989-1999). Fifty of 54 deaths were due to AIDS. There were significant associations (P
ISSN:	0934-9723 1435-4373
DOI:	10.1007/s100960100486