Bacterial pili: molecular mechanisms of pathogenesis

Gram-negative bacteria produce a diverse array of pili that mediate microbe–microbe and host–pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the...

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Veröffentlicht in:	Current Opinion in Microbiology 2000-02, Vol.3 (1), p.65-72
Hauptverfasser:	Sauer, Frederic G, Mulvey, Matthew A, Schilling, Joel D, Martinez, Juan J, Hultgren, Scott J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion Bacterial Proteins - metabolism Complementation Cytokines - metabolism Donor strand Escherichia coli - metabolism Escherichia coli - pathogenicity Escherichia coli - ultrastructure Escherichia coli Infections - metabolism Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Fimbriae, Bacterial - genetics Fimbriae, Bacterial - metabolism Host–pathogen interactions Humans Molecular Chaperones - metabolism Pathogenesis Pilus structure Signaling Urinary Tract Infections - metabolism Urinary Tract Infections - microbiology Urinary Tract Infections - pathology
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Beschreibung
Zusammenfassung:	Gram-negative bacteria produce a diverse array of pili that mediate microbe–microbe and host–pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/S1369-5274(99)00053-3