Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling

Recent structural studies have supported a kinetic model of TCR activation, raising the question of how the duration of receptor occupancy is translated into activation of immune response genes. We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the dur...

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Veröffentlicht in:	Current Opinion in Immunology 2001-06, Vol.13 (3), p.346-350
Hauptverfasser:	Neilson, Joel, Stankunas, Kryn, Crabtree, Gerald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - immunology Animals calcineurin Calcineurin - physiology Calcium-Calmodulin-Dependent Protein Kinases - physiology Cell Nucleus - enzymology Cell Nucleus - immunology Cell Nucleus - metabolism DNA-Binding Proteins - metabolism Glycogen Synthase Kinase 3 GSK-3 Humans Microtubule-Associated Proteins - physiology NF-AT NF-AT protein NFATC Transcription Factors Nuclear Proteins Receptors, Antigen, T-Cell - metabolism TCR Transcription Factors - metabolism
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Zusammenfassung:	Recent structural studies have supported a kinetic model of TCR activation, raising the question of how the duration of receptor occupancy is translated into activation of immune response genes. We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the duration of receptor occupancy.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/S0952-7915(00)00225-9