From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility

The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins....

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Veröffentlicht in:	Current Opinion in Neurobiology 2000-02, Vol.10 (1), p.80-87
Hauptverfasser:	Lanier, Lorene M, Gertler, Frank B
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl protein Actins - metabolism Animals Cell Adhesion Cell Adhesion Molecules - metabolism Cell Movement Cytoskeleton - metabolism Drosophila Proteins Growth Cones - enzymology Growth Cones - physiology Phosphorylation Protein Binding Protein Tyrosine Phosphatases - metabolism Proto-Oncogene Proteins c-abl - metabolism Receptor-Like Protein Tyrosine Phosphatases rho GTP-Binding Proteins - metabolism
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Beschreibung
Zusammenfassung:	The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/S0959-4388(99)00058-6