Actin machinery: pushing the envelope
The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation co...
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| Veröffentlicht in: | Current Opinion in Cell Biology 2000-02, Vol.12 (1), p.104-112 |
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| container_title | Current Opinion in Cell Biology |
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| creator | Borisy, Gary G Svitkina, Tatyana M |
| description | The reconstitution of microbial rocketing motility
in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility. |
| doi_str_mv | 10.1016/S0955-0674(99)00063-0 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Current Opinion in Cell Biology, 2000-02, Vol.12 (1), p.104-112 |
| issn | 0955-0674 1879-0410 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Actin Depolymerizing Factors Actin-Related Protein 2 Actin-Related Protein 3 Actins - metabolism Animals Contractile Proteins Cytoskeletal Proteins Dendrites - metabolism Destrin Humans Microfilament Proteins - metabolism Models, Biological Molecular Motor Proteins - metabolism Profilins |
| title | Actin machinery: pushing the envelope |
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