Actin machinery: pushing the envelope

The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation co...

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Veröffentlicht in:	Current Opinion in Cell Biology 2000-02, Vol.12 (1), p.104-112
Hauptverfasser:	Borisy, Gary G, Svitkina, Tatyana M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors Actin-Related Protein 2 Actin-Related Protein 3 Actins - metabolism Animals Contractile Proteins Cytoskeletal Proteins Dendrites - metabolism Destrin Humans Microfilament Proteins - metabolism Models, Biological Molecular Motor Proteins - metabolism Profilins
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Beschreibung
Zusammenfassung:	The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/S0955-0674(99)00063-0